A versatile functional interaction between electrically silent K_V subunits and K_V7 potassium channels.

ABSTRACT: Voltage-gated K⁺ (K_V) channels govern K⁺ ion flux across cell membranes in response to changes in membrane potential. They are formed by the assembly of four subunits, typically from the same family. Electrically silent K_V channels (K_VS), however, are unable to conduct currents on their own. It has been assumed that these K_VS must obligatorily assemble with subunits from the K_V2 family into heterotetrameric channels, thereby giving rise to currents distinct from those of homomeric K_V2 channels. Herein, we show that K_VS subunits indeed also modulate the activity, biophysical properties and surface expression of recombinant K_V7 isoforms in a subunit-specific manner. Employing co-immu

SUBMITTER: Renigunta V 

PROVIDER: S-EPMC11335225 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature