Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons.

ABSTRACT: Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of cancer chemotherapy that can often limit treatment options for cancer patients or have life-long neurodegenerative consequences that reduce the patient's quality of life. CIPN is caused by the detrimental actions of various chemotherapeutic agents on peripheral axons. Currently, there are no approved preventative measures or treatment options for CIPN, highlighting the need for the discovery of novel therapeutics and improving our understanding of disease mechanisms. In this study, we utilized human-induced pluripotent stem cell (hiPSC)-derived motor neurons as a platform to mimic axonal damage after treatment with vincristine, a chemotherapeutic used for the treatment of breast cancers, osteosarcomas, and leuk

SUBMITTER: Petrova V 

PROVIDER: S-EPMC11335239 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature