VEGFD signaling balances stability and activity-dependent structural plasticity of dendrites.

ABSTRACT: Mature neurons have stable dendritic architecture, which is essential for the nervous system to operate correctly. The ability to undergo structural plasticity, required to support adaptive processes like memory formation, is still present in mature neurons. It is unclear what molecular and cellular processes control this delicate balance between dendritic structural plasticity and stabilization. Failures in the preservation of optimal dendrite structure due to atrophy or maladaptive plasticity result in abnormal connectivity and are associated with various neurological diseases. Vascular endothelial growth factor D (VEGFD) is critical for the maintenance of mature dendritic trees. Here, we describe how VEGFD affects the neuronal cytoskeleton and demonstrate that VEGFD exerts its effects o

SUBMITTER: Aksan B 

PROVIDER: S-EPMC11335284 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature