Characterization of an Estrogen Receptor α-Selective ¹⁸ F-Estradiol PET Tracer.

ABSTRACT: Objective  Conventional imaging of cancer with modalities such as computed tomography or magnetic resonance imaging provides little information about the underlying biology of the cancer and consequently little guidance for systemic treatment choices. Accurate identification of aggressive cancers or those that are likely to respond to specific treatment regimens would allow more precisely tailored treatments to be used. The expression of the estrogen receptor α subunit is associated with a more aggressive phenotype, with a greater propensity to metastasize. We aimed to characterize the binding properties of an ¹⁸ F-estradiol positron emission tomography (PET) tracer in its ability to bind to the α and β forms of estrogen receptors in vitro and confirmed its binding to est

SUBMITTER: Sluka P 

PROVIDER: S-EPMC11335392 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature