Pathogenicity characteristics of different subgenotype pseudorabies virus in newborn piglets.

ABSTRACT: Pseudorabies virus is a major pathogen in the pig industry, causing substantial economic losses. The emergence of pseudorabies virus variant strains in China has led to extensive spread, raising concerns about their potential impact. However, the differences in pathogenicity between the classical strains and the variant strains of genotype II are not well understood. In this study, we isolated three pseudorabies virus strains to evaluate their replication characteristics and to examine the differences in virulence genes among various subgenotypes strains. Additionally, a piglet infection model was utilized to investigate the clinical features of infection, tissue tropism, and the inflammatory responses induced by these strains. Our results showed that the genotype II variant strains (MS, X

SUBMITTER: Xu L 

PROVIDER: S-EPMC11335603 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature