Comprehensive mendelian randomization reveals atrial fibrillation-breast cancer relationship and explores common druggable targets.

ABSTRACT:

Background

Atrial fibrillation (AF) and breast cancer pose significant risks to human health. The reasons behind the concurrent occurrence of AF and breast cancer remain unclear, leading to complex treatment approaches. Mendelian Randomization (MR) analyses aim to offer genetic evidence supporting the causation of AF and breast cancer and to investigate common druggable genes associated with both conditions.

Methods

We used two-samples of MR to sequentially explore the causal relationship between atrial fibrillation and breast cancer, and between atrial fibrillation and breast cancer therapeutic drugs, and verified the stability of the results through colocalization analysis. We utilized the Connectivity map database to infer the direction of drug effects on disease. Finally

SUBMITTER: Qi F 

PROVIDER: S-EPMC11335625 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature