Interplay between immune cells and metabolites in epilepsy: insights from a Mendelian randomization analysis.

ABSTRACT:

Background

Epilepsy is associated with the immune system and metabolism; however, its etiology remains insufficiently understood. Here, we aim to elucidate whether circulating immune cell profiles and metabolites impact the susceptibility to epilepsy.

Methods

We used publicly available genetic data and two-sample Mendelian randomization (MR) analyses to establish causal relationships and mediating effects between 731 immune cells and 1,400 metabolites associated with epilepsy. Sensitivity analyses were conducted to detect heterogeneity and horizontal pleiotropy in the study results.

Results

MR analysis examining the relationship between immune cells, metabolites, and epilepsy revealed significant causal associations with 28 different subtypes of immune cells and 14 me

SUBMITTER: Wang K 

PROVIDER: S-EPMC11335650 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature