DNA damage (8-OHdG) and telomere length in captive Psittacidae birds with different longevity.

ABSTRACT: Aging is a complex process influenced by internal and external factors. Oxidative stress damages DNA, leading to 8-hydroxy-2' deoxyguanosine formation (8-OHdG). Telomere shortening is considered a biomarker of aging and oxidative stress may enhance its attrition. The ability to manage and repair oxidative stress varies among species and life histories. Avian species, such as Psittacidae birds, exhibit exceptional lifespans despite their physiological characteristics that might suggest otherwise. This study investigates 8-OHdG levels in serum samples from long- and short-lived birds of the order Psittaciformes, examining their relationship with telomere length and antioxidant capacity based on lifespan strategies. Among 43 individuals analyzed 26 belonged to the "long-lived species" group a

SUBMITTER: Dominguez-de-Barros A 

PROVIDER: S-EPMC11335655 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature