Hemodynamic gain index and risk of chronic kidney disease: A prospective cohort study of middle-aged and older men.

ABSTRACT: The hemodynamic gain index (HGI), a novel non-invasive hemodynamic marker, represents a promising advancement in cardiovascular risk assessment. Cardiovascular disease and chronic kidney disease (CKD) are closely intertwined and share bidirectional relationships. We aimed to assess the association of HGI with CKD risk in a prospective study. Hemodynamic gain index was calculated using heart rate and systolic blood pressure (SBP) responses measured in 1765 men aged 42-61 years with normal kidney function during exercise testing using the formula: [(Heart rate_max x SBP_max)-(Heart rate_rest x SBP_rest)]/(Heart rate_rest x SBP_rest). Multivariable adjusted hazard ratios (HRs) (95% confidence intervals, CIs) were estimated for CKD. O

SUBMITTER: Kunutsor SK 

PROVIDER: S-EPMC11335700 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature