Assessment of the potential risks in SD rats gavaged with genetically modified yeast containing the cp4-epsps gene.

ABSTRACT:

Introduction

Despite the absence of definitive evidence indicating that the cp4-epsps gene and its resultant recombinant proteins have significant harmful effects on either human or animal health, the safety assessment of genetically modified (GM) crops expressing the CP4-EPSPS proteins has been controversial. This study endeavor was aimed at evaluating the potential risks posed by the CP4-EPSPS protein in transgenic crops, thereby contributing to the advancement of risk assessment methodologies in the context of genetically engineered crops.

Methods

To ascertain the appropriate daily dosages for oral gavage administration, the expression levels of the CP4-EPSPS protein in a recombinant yeast were quantified. Subsequently, physiological and biochemical analysis, metabolomics

SUBMITTER: Bi B 

PROVIDER: S-EPMC11335726 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature