Differential effect of surgical technique on intravesical recurrence after radical nephroureterectomy in patients with upper tract urothelial cancer: a systematic review and Meta-analysis.

ABSTRACT:

Context

Radical nephroureterectomy (RNU) with bladder cuff resection is the standard treatment in patients with high-risk upper tract urothelial cancer (UTUC). However, it is unclear which specific surgical technique may lead to improve oncological outcomes in term of intravesical recurrence (IVR) in patients with UTUC.

Objective

To evaluate the efficacy of surgical techniques and approaches of RNU in reducing IVR in UTUC patients.

Evidence acquisition

Three databases were queried in January 2024 for studies analyzing UTUC patients who underwent RNU. The primary outcome of interest was the rate of IVR among various types of surgical techniques and approaches of RNU.

Evidence synthesis

Thirty-one studies, comprising 1 randomized controlled trial and 1 prospectiv

SUBMITTER: Tsuboi I 

PROVIDER: S-EPMC11335797 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature