WNT5A is a putative epi-driver of prostate cancer metastasis to the bone.

ABSTRACT:

Background

Current diagnostic tools are unable to distinguish low-grade indolent prostate cancer (PrCa) from that with a propensity to become metastatic and/or lethal. Recent evidence suggests that reprogramming of the transcriptome may drive the metastatic phenotype, and that this reprogramming is controlled, at least in part, by epigenetic changes to the DNA of cancer cells, including methylation. These changes, referred to as 'epigenetic drivers,' have previously been associated with cancer cell survival.

Methods

Here, using Illumina Methylation EPIC array data of paired primary PrCa and metastatic bone samples, we identified WNT5A as a putative epi-driver of PrCa metastasis to the bone, which was further validated in vitro.

Results

Significantly higher WNT5A methy

SUBMITTER: Wilkinson EJ 

PROVIDER: S-EPMC11335815 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature