Clinical significance of sarcopenia in children with neuroblastic tumors.

ABSTRACT:

Purpose

To elucidate the clinical significance of sarcopenia in children with neuroblastic tumors (NTs).

Methods

We conducted a retrospective observational study and analyzed the z-scores for height, body weight, body mass index, and skeletal muscle index (HT-z, BW-z, BMI-z, and SMI-z) along with the clinical characteristics of 36 children with NTs. SMI-z was calculated from 138 computed tomography scans at diagnosis, during treatment, and at follow-up. The International Neuroblastoma Risk Group classification was used to identify high-risk groups. We analyzed the data at diagnosis for prognostic analysis and changes over time after diagnosis in the HT-z, BW-z, BMI-z, and SMI-z groups.

Results

Among the four parameters at diagnosis, only SMI-z predicted overall surviv

SUBMITTER: Kudo W 

PROVIDER: S-EPMC11335913 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature