High-resolution epidemiological landscape from  ~290,000 SARS-CoV-2 genomes from Denmark.

ABSTRACT: Vast amounts of pathogen genomic, demographic and spatial data are transforming our understanding of SARS-CoV-2 emergence and spread. We examined the drivers of molecular evolution and spread of 291,791 SARS-CoV-2 genomes from Denmark in 2021. With a sequencing rate consistently exceeding 60%, and up to 80% of PCR-positive samples between March and November, the viral genome set is broadly whole-epidemic representative. We identify a consistent rise in viral diversity over time, with notable spikes upon the importation of novel variants (e.g., Delta and Omicron). By linking genomic data with rich individual-level demographic data from national registers, we find that individuals aged  < 15 and  > 75 years had a lower contribution to molecular change (i.e., branch lengths) compared to other

SUBMITTER: Khurana MP 

PROVIDER: S-EPMC11335946 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature