Growth hormone-receptor disruption in mice reduces osteoarthritis and chondrocyte hypertrophy.

ABSTRACT: Excessive growth hormone (GH) has been shown to promote joint degeneration in both preclinical and clinical studies. Little is known about the effect of disrupted GH or GH receptor (GHR) on joint health. The goal of this study is to investigate joint pathology in mice with either germline (GHR^-/-) or adult inducible (iGHR^-/-) GHR deficiency. Knee joints from male and female GHR^-/- and WT mice at 24 months of age were processed for histological analysis. Also, knee joints from male and female iGHR^-/- and WT mice at 22 months of age were scanned by micro-CT (μCT) for subchondral bone changes and characterized via histology for cartilage degeneration. Joint sections were also stained for the chondrocyte hypertrophy marker, COLX, and the cartilage de

SUBMITTER: Liu H 

PROVIDER: S-EPMC11336010 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature