BAX and DDB2 as biomarkers for acute radiation exposure in the human blood ex vivo and non-human primate models.

ABSTRACT: There are currently no available FDA-cleared biodosimetry tools for rapid and accurate assessment of absorbed radiation dose following a radiation/nuclear incident. Previously we developed a protein biomarker-based FAST-DOSE bioassay system for biodosimetry. The aim of this study was to integrate an ELISA platform with two high-performing FAST-DOSE biomarkers, BAX and DDB2, and to construct machine learning models that employ a multiparametric biomarker strategy for enhancing the accuracy of exposure classification and radiation dose prediction. The bioassay showed 97.92% and 96% accuracy in classifying samples in human and non-human primate (NHP) blood samples exposed ex vivo to 0-5 Gy X-rays, respectively up to 48 h after exposure, and an adequate correlation between reconstructed and ac

SUBMITTER: Kanagaraj K 

PROVIDER: S-EPMC11336173 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature