Nickel(II)/BINOL-catalyzed enantioselective C-H activation via desymmetrization and kinetic resolution.

ABSTRACT: The field of nickel catalysis has witnessed remarkable growth in recent years. However, the use of nickel catalysts in enantioselective C-H activation remains a daunting challenge because of their variable oxidation states, intricate coordination chemistry, and unpredictable reactivity patterns. Herein, we report an enantioselective C-H activation reaction catalyzed by commercially available and air-stable nickel(II) catalyst. Readily available and simple (S)-BINOL is used as a chiral ligand. This operationally simple protocol enables the synthesis of planar chiral metallocenes in high yields with excellent enantioselectivity through desymmetrization and kinetic resolution. Air-stable planar chiral nickelacycle intermediates are first synthesized via enantioselective C-H nickelation and sh

SUBMITTER: Yao QJ 

PROVIDER: S-EPMC11336223 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature