Causal relationships between immune cells, inflammatory factors, serum metabolites, and hepatic cancer: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies and clinical trials suggest associations between immune cells, inflammatory factors, serum metabolites, and hepatic cancer. However, the causal relationships between these factors and hepatic cancer remain to be established.

Objective

To explore the causal relationships between immune cells, inflammatory factors, serum metabolites, and hepatic cancer.

Methods

This study employed comprehensive two-sample Mendelian randomization (MR) utilizing publicly available genetic data (GWAS) to analyze causal relationships between 731 immune cell traits, 91 inflammatory factors, 1400 serum metabolites, and hepatic cancer. The primary analysis used inverse variance-weighted (IVW) MR, with additional sensitivity tests to assess the validity of causa

SUBMITTER: Chen H 

PROVIDER: S-EPMC11336366 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature