A literature review of genetics and epigenetics of HCV-related hepatocellular carcinoma: translational impact.

ABSTRACT:

Background and objective

Hepatocellular carcinoma (HCC) poses a significant global health burden and ranks as the fifth most prevalent cancer on a global scale. Hepatitis C virus (HCV) infection remains one of the major risk factors for HCC development. HCC is a heterogeneous disease, and the development of HCC caused by HCV is intricate and involves various factors, including genetic susceptibility, viral factors, immune response due to chronic inflammation, alcohol abuse, and metabolic dysfunction associated with fatty liver disease. In this review, we provide a comprehensive and updated review of research on the genetics and epigenetic mechanisms implicated in developing HCC associated with HCV infection. We also discuss the potential translational implications, including novel

SUBMITTER: Pan Z 

PROVIDER: S-EPMC11336528 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature