Integrative analysis of causal associations between neurodegenerative diseases and colorectal cancer.

ABSTRACT:

Background

Observational studies have shown that the correlation between neurodegenerative diseases and colorectal cancer (CRC) remains controversial. Therefore, this study aimed to verify the causal association between these two diseases.

Methods

Mendelian randomization (MR) analysis was used to assess the causal relationships between five major neurodegenerative diseases and CRC. Multivariable MR (MVMR) analysis was conducted to assess the direct causal effect of neurodegenerative diseases on CRC. Colocalization and pathway enrichment analyses were conducted to further elucidate our results. Sensitivity analysis was conducted to assess the robustness of the results.

Results

Genetically predicted Alzheimer's disease (AD) nominally increased CRC risk (OR = 1.0620, 95%

SUBMITTER: Wang F 

PROVIDER: S-EPMC11336615 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature