Exploring urinary proteomics and peptidomics biomarkers for the diagnosis of mekong schistosomiasis.

ABSTRACT: Schistosomiasis caused by Schistosoma mekongi is one of the causative agents of human blood fluke infection in the lower Mekong River. Traditionally, the detection of egg morphology in stool samples has served as the prevailing method for diagnosing Schistosoma infection. Nonetheless, this approach exhibits low sensitivity, particularly in early infection detection. Urine has been extensively studied as a noninvasive clinical sample for diagnosing infectious diseases. Despite this, urine proteomic analysis of S. mekongi infection has been less investigated. This study aimed to characterize proteins and peptides present in mouse urine infected with S. mekongi both before infection and at intervals of 1, 2, 4, and 8 weeks post-infection using mass spectrometry-bas

SUBMITTER: Thiangtrongjit T 

PROVIDER: S-EPMC11336616 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature