Tirofiban prevents the effects of SARS-CoV-2 spike protein on macrophage activation and endothelial cell death.

ABSTRACT: SARS-CoV-2 viral-derived particles have been proposed to have a causal role in tissue inflammation. Macrophage is the culprit cell in the pathogenesis of destructive inflammatory response to the SARS-CoV-2 virus. We investigated whether the spike protein might play a role in perturbing the physiological process of resolution of inflammation. Using an in vitro model of M2 polarized macrophages, we found that recombinant spike protein produced typical M1 morphological features in these alternative differentiated cells. In the presence of spike, M2-macrophages lose their elongated morphology, become rounded and acquire a strong capability to stimulate lymphocyte activation and proliferation. Moreover, in M2 macrophages, spike activated the signal transducer and activator-1 (STAT1) the pivotal

SUBMITTER: Marrone L 

PROVIDER: S-EPMC11336627 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature