NINJ1 Facilitates Abdominal Aortic Aneurysm Formation via Blocking TLR4-ANXA2 Interaction and Enhancing Macrophage Infiltration.

ABSTRACT: Abdominal aortic aneurysm (AAA) is a common and potentially life-threatening condition. Chronic aortic inflammation is closely associated with the pathogenesis of AAA. Nerve injury-induced protein 1 (NINJ1) is increasingly acknowledged as a significant regulator of the inflammatory process. However, the precise involvement of NINJ1 in AAA formation remains largely unexplored. The present study finds that the expression level of NINJ1 is elevated, along with the specific expression level in macrophages within human and angiotensin II (Ang II)-induced murine AAA lesions. Furthermore, Ninj1^flox/flox and Ninj1^flox/floxLyz2-Cre mice on an ApoE^-/- background are generated, and macrophage NINJ1 deficiency inhibits AAA formation and reduces macrophage infiltration

SUBMITTER: Wu Z 

PROVIDER: S-EPMC11336960 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature