Bis(pinacolato)diboron-Enabled Ni-Catalyzed Reductive Arylation/Vinylation of Alkyl Electrophiles.

ABSTRACT: Herein, the use of economically and environmentally friendly bis(pinacolato)diboron (B₂Pin₂) is described as a non-metallic reductant in mediating Ni-catalyzed C(sp³)-C(sp²) reductive cross-coupling of alkyl electrophiles with aryl/vinyl halides. This method exhibits excellent suitability for heteroaryl halides and alkyl halides/Katritzky salts. The present study is compatible with an in situ halogenation of alcohol method, allowing for selective mono-functionalization of diols and bio-relevant alcohols (e.g., carbohydrates). The use of B₂Pin₂ shows potential for easy scalability without introducing additional metal impurities into the products. It is observed for the first time in the realm of cross-electrophile coupling ch

SUBMITTER: Sun D 

PROVIDER: S-EPMC11336967 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature