Sacubitril-Valsartan in Patients Requiring Hemodialysis.

ABSTRACT:

Importance

Randomized clinical trials have shown that sacubitril-valsartan reduces the risks of mortality and hospitalization in patients with heart failure with reduced ejection fraction (HFrEF), but patients with kidney failure requiring dialysis were excluded.

Objective

To investigate the comparative effectiveness of sacubitril-valsartan vs angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ACEIs or ARBs) in patients with HFrEF requiring hemodialysis.

Design, setting, and participants

This retrospective, 1:1 propensity score-matched comparative effectiveness study included patients who were 18 years or older with HFrEF, enrolled in Medicare Parts A, B, and D, and survived at least 90 days receiving in-center hemodialysis from July 8, 2015, t

SUBMITTER: Le D 

PROVIDER: S-EPMC11337068 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature