FaSTPACE: a fast and scalable tool for peptide alignment and consensus extraction.

ABSTRACT: Several novel high-throughput experimental techniques have been developed in recent years that generate large datasets of putative biologically functional peptides. However, many of the computational tools required to process these datasets have not yet been created. In this study, we introduce FaSTPACE, a fast and scalable computational tool to rapidly align short peptides and extract enriched specificity determinants. The tool aligns peptides in a pairwise manner to produce a position-specific global similarity matrix for each peptide. Peptides are realigned in an iterative manner scoring the updated alignment based on the global similarity matrices of the peptides and updating the global similarity matrices based on the new alignment. The method then iterates until the global similarity

SUBMITTER: Kotb HM 

PROVIDER: S-EPMC11337127 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature