Glucose Metabolism and Sex Hormones in Male Patients with Medication-naive First-episode Schizophrenia: A Large-scale Cross-sectional Study.

ABSTRACT:

Background

Schizophrenia (SCZ) usually begins in early adult life. The underlying molecular mechanisms of SCZ remain unclear. There is evidence for the involvement of abnormalities in metabolic and endocrine systems in SCZ, even in drug-naïve first-episode schizophrenia patients (DNFES). However, the association between impaired regulation of glucose metabolism and sex hormones was not studied in SCZ. This study aimed to evaluate the interrelationship between sex hormones and high fasting glucose levels in male DNFES patients.

Methods

A total of 99 patients with SCZ were recruited, and fasting glucose, fasting insulin, the insulin resistance index (HOMA-IR), and sex hormones were measured.

Results

We found that some male patients with SCZ had abnormal levels in glucos

SUBMITTER: Xiu M 

PROVIDER: S-EPMC11337684 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature