Dual bacteriocin and extracellular vesicle-mediated inhibition of <i>Campylobacter jejuni</i> by the potential probiotic candidate <i>Ligilactobacillus salivarius</i> UO.C249.

ABSTRACT: Campylobacter jejuni (C. jejuni) is one of the most common causes of foodborne infections worldwide and a major contributor to diarrheal diseases. This study aimed to explore the ability of commensal gut bacteria to control C. jejuni infection. Bacterial strains from the intestinal mucosa of broilers were screened in vitro against C. jejuni ATCC BAA1153. The cell-free supernatant (CFS) of Ligilactobacillus salivarius UO.C249 showed potent dose-dependent antimicrobial activity against the pathogen, likely due to the presence of bacteriocin-like moieties, as confirmed by protease treatment. Genome and exoproteome analyses revealed the presence of known bacteriocins, including Abp118. The genome of Lg. salivarius UO.C249 harbors a 1.8-Mb chromo

SUBMITTER: Chiba M 

PROVIDER: S-EPMC11337818 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature