Nitrate promotes the growth and the production of short-chain fatty acids and tryptophan from commensal anaerobe <i>Veillonella dispar</i> in the lactate-deficient environment by facilitating the catabolism of glutamate and aspartate.

ABSTRACT: Veillonella spp. are nitrate-reducing bacteria with anaerobic respiratory activity that reduce nitrate to nitrite. They are obligate anaerobic, Gram-negative cocci that ferment lactate as the main carbon source and produce short-chain fatty acids (SCFAs). Commensal Veillonella reside in the human body site where lactate level is, however, limited for Veillonella growth. In this study, nitrate was shown to promote the anaerobic growth of Veillonella in the lactate-deficient media. We aimed to investigate the underlying mechanisms and the metabolism involved in nitrate respiration. Nitrate (15 mM) was demonstrated to promote Veillonella dispar growth and viability in the tryptone-yeast extract medium containing 0.5 mM L-lactate. Metabolite and transcriptomi

SUBMITTER: Hung J-H 

PROVIDER: S-EPMC11337843 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature