Prevalence of Apical Periodontitis in Saudi Arabia: A Systematic Review and Meta-analysis
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ABSTRACT:
SUBMITTER: Hakeem F
PROVIDER: S-EPMC11337961 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
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| S-EPMC10960097 | biostudies-literature
Project description:BackgroundThe current systematic review and meta-analysis was conducted to estimate the prevalence of fibromyalgia syndrome (FMS) in Saudi Arabia.MethodsA PRISMA systematic search appraisal and meta-analysis were conducted. A systematic literature search of English publications in PubMed, Embase, PsycINFO, Web of Science, MEDLINE, and Google Scholar, was conducted up to December 2022. Generic, methodological and statistical data was extracted from the eligible studies. Meta-analysis was done using Comprehensive Meta-Analysis Software. The effect size estimates were calculated using the Fail-Safe N test. The funnel plot, Begg's and Mazumdar's rank correlation tests were employed to find any potential bias. The strength of the association between two variables is assessed using Kendall's tau. A fixed-effects model for the meta-analysis.ResultsThe literature search yielded a total of 2479 studies. Eight papers were included in the final analysis with sample size ranging 40 to 1686. All studies were cross-sectional except two, which were retrospective. The total number of the participants recruited in the included articles was 4967 (1794 males and 3173 females); with age ranged between 20 and 79 years. There was high heterogeneity among studies articles (Q = 270.187; p-value 0.001); the tau value was 0.179. The pooled event rates and the 95% confidence intervals (CIs) for the prevalence of FMS in Saudi Arabia in a fixed-effects model was 13.4% (95% CI: 0.124-0.144).ConclusionOur results clearly demonstrate that FMS is highly prevalent (13.4%) in Saudi Arabia. It also more common among women. The high prevalence of FMS in Saudi Arabia should be seriously considered and planners should take steps to reduce it.
| S-EPMC10466693 | biostudies-literature
Project description:The prevalence of Tuberculosis (TB) serves as a pivotal metric, reflecting the TB burden within a specific demographic. It quantifies the number of individuals affected by either active TB disease or latent TB (LTBI). Such data is crucial for assessing the efficacy of TB control interventions and determining the demand for diagnostic and treatment services. This study aims to consolidate data on TB infection prevalence in Saudi Arabia from existing literature. Additionally, we stratify this prevalence based on age, professional involvement in healthcare, gender, and region. Our search was conducted in PubMed, Scopus, Cochrane Library, and Web of Science databases to determine relevant studies. The pooled prevalence of TB infection among the total population residing in Saudi Arabia was estimated using a random-effect meta-analysis approach and Comprehensive Meta-Analysis software. The protocol was registered in the PROSPERO International Prospective Register of Systematic Reviews, No: CRD42023400984. We included 21 studies, 11 of which were pooled in the analysis. The overall prevalence was 17%.Regarding the specific population, we found that the prevalence of TB in Saudi Arabia was 9.8% and 26.7% in the general population and the healthcare workers, respectively. Stratifying by age, the highest prevalence was observed in individuals over 50 years (33.0%), while the lowest was in the 10-19 age group (6.4%). In terms of gender, men had a higher prevalence (12.0%) compared to women (9.4%). The prevalence of TB in Riyadh was 6.4%, and 3.6% in Mecca and Medina. Among healthcare workers, nurses and physicians had a prevalence of 14.7% and 15.0%, respectively. Our study found a TB prevalence of 17.0% in Saudi Arabia, higher than the worldwide average of 12.0%. Men had a higher prevalence than women, and healthcare workers had a relatively low prevalence compared to other countries. Age was a significant risk factor, with the highest prevalence in individuals above 50 years. Standardized protocols for screening and diagnosis and targeted interventions are needed to combat TB effectively in the country.
| S-EPMC11442870 | biostudies-literature
Project description:Osteoporosis is a common systemic bone disorder in the elderly, characterized by low bone mineral density and deterioration of bone structure. Apical periodontitis is an inflammatory response to the microbial infection of root canals, typically characterized by apical bone destruction surrounding the tooth's apex. This systematic review aimed to determine if osteoporosis affects the prevalence of apical periodontitis in adults. PRISMA guidelines have been followed. It included randomized clinical trials, cross-sectional, cohort, and case-control studies, and excluded non-relevant investigations and various secondary sources. A comprehensive search was performed in PubMed, Scopus, and Web of Science, until 13 March 2024. The Newcastle-Ottawa Scale was used to assess the quality of the three selected studies: two cross-sectional studies and one case-control study. One investigation only included post-menopausal women recruited at a dental university clinic, the other integrated data from the total hospital patients' population, and the third selected patients referred to the university dental clinic from the university hospital. The findings varied: one study noted a marginal association between low bone mineral density and apical periodontitis, another found a significant association, and the third, with the lowest risk of bias, reported no link. The main limitations were the scarcity of eligible studies and their overall quality. The review was registered in the PROSPERO database (CRD42024523705), applied strict inclusion criteria and thorough searches by experienced and independent reviewers. There is no strong evidence that adult individuals with osteoporosis have a higher probability of developing apical periodontitis. However, clinicians should remain cautious of osteoporosis's potential impact on apical periodontitis development.
| S-EPMC11354161 | biostudies-literature
Project description:Toxoplasmosis is one of the most common parasites affecting humans in diverse populations caused by T. gondii. This study aims to systematically review and analyze the prevalence of T. gondii infection among various population categories in Saudi Arabia. Our search was done in five databases: PubMed, Scopus, Cochrane Library, Embase, and Web of Science to find the relevant studies from inception to November 2023. The pooled prevalence of toxoplasmosis among the total population living in Saudi Arabia was estimated using a random-effect meta-analysis approach, and Comprehensive Meta-Analysis software was utilized for this analysis. Our study included 30 case-control and retrospective studies published from 1994 to 2023 involving 20,699 patients from different regions in the Kingdom of Saudi Arabia. Various cities were included, such as Al-Ahsa, Najran, Riyadh, Arar, Mecca, al Khobar, Mushait, Tabuk, jazan, Hail City, Almadinah Almunawwarah, AL-Ahsa, and Abha; 27 reported outcomes related to IgG seroprevalence, revealing an overall toxoplasmosis prevalence of 27.5% in Saudi Arabia. Fifteen studies that measured IgM seroprevalence found an overall toxoplasmosis prevalence of 2.2%. Specifically for pregnant women, IgG seroprevalence was 28%. Among different age categories, the highest toxoplasmosis prevalence was observed in the group aged 31-45 years, reaching 32.5%, while the lowest prevalence was in the 10-20 years category at 19.3%. Regarding gravidity, the grand multi-gravida group exhibited the highest prevalence at 32.9%, with an upper limit of 47.8%. Furthermore, individuals who consumed freshwater demonstrated a higher incidence than those drinking bottled water, with respective prevalence rates of 33.5% and 29.4%. In conclusion, the prevalence of toxoplasmosis in Saudi Arabia is lower than the global average, with significant variations across different age groups, water sources, and dietary habits. Targeted educational programs and public health interventions are essential to raise awareness and reduce the risk of T. gondii infection. Future research should focus on improving study quality and exploring the broader implications of toxoplasmosis on public health in Saudi Arabia.
| S-EPMC11652434 | biostudies-literature
Project description:IntroductionDuring the last two decades, several studies have been published regarding the prevalence of tobacco smoking among college students in the Kingdom of Saudi Arabia (KSA). This systematic review and meta-analysis is intended to determine and examine the smoking prevalence in Saudi college students from 2010-2018.MethodsPubMed, Science Direct, APA PsycNET, Web of Science, and CINAHL were used to search for published articles reporting the smoking prevalence among Saudi college students. After eliminating irrelevant articles, investigators independently assessed the quality of each article, based on Russell & Gregory guidelines. MetaXL software was used to calculate the pooled prevalence among included studies, using the IVhert model. Heterogeneity among the included studies was evaluated, using I2 statistic. Sensitivity analyses were conducted between male and female genders.ResultsOf the 295 published articles, 29 articles used a cross-sectional design to determine smoking prevalence among Saudi college students. Most of the studies were conducted in Riyadh at health-science-related colleges; the rest were performed in different cities and colleges. The meta-analysis showed that the pooled estimate of smoking prevalence among college students in the KSA was 17% (95% CI: 11-23%). Saudi male students had a prevalence rate of 26% (95% CI: 24-29%), whereas for Saudi female students the prevalence was 5% (95% CI: 3-7%).ConclusionsSmoking among Saudi college students was higher than in the majority of regional countries (e.g. Iran). Saudi male students had a higher smoking prevalence than Saudi female college students. Additionally, studies that reported a high prevalence targeted students in specific disciplines. Public health authorities in the KSA should develop a surveillance system that monitors the prevalence of tobacco smoking on campuses. A surveillance system of monitoring tobacco use among Saudi college students could be beneficial in determining the degree of the tobacco problem and in improving current tobacco control programs.
| S-EPMC6662783 | biostudies-literature
Project description:Neglected tropical diseases (NTDs) pose a significant public health challenge in tropical and subtropical regions, particularly in the Kingdom of Saudi Arabia (KSA), where epidemiological data remain scarce. These diseases disproportionately affect vulnerable populations, leading to chronic morbidity and economic burdens. Understanding their distribution and burden is crucial for effective public health interventions. This study aimed to systematically evaluate the prevalence, distribution, and etiological patterns of NTDs in KSA, identifying key research gaps and informing future policy directions. A systematic review and meta-analysis were conducted on peer-reviewed studies published between 1950 and 2024 that investigated NTDs in humans in KSA. Ninety-four articles met the inclusion criteria. The majority (69.15%, n = 65) were published after 2010, with most studies concentrated in the western (n = 35, 37.23%) and southwestern (n = 15, 15.96%) regions, areas known for environmental and socioeconomic factors that may contribute to disease transmission. Protozoal NTDs were the most frequently reported (n = 28, 29.78%), followed by viral (n = 26, 27.66%), helminthic (n = 18, 19.15%), and ectoparasitic (n = 9, 9.57%) infections. Bacterial (n = 5, 5.32%), fungal (n = 4, 4.26%), and venom-related (n = 4, 4.26%) NTDs were less commonly reported. Meta-analysis yielded pooled prevalence estimates of leishmaniasis at 0.59 (95% CI: 0.38-0.77, I² = 94.2%) and dengue at 0.20 (95% CI: 0.05-0.53, I² = 98.8%), highlighting a substantial disease burden and high heterogeneity among studies. The findings emphasize the urgent need for strengthened national surveillance, improved diagnostic capacity, and region-specific interventions to control NTDs in KSA. Future research should focus on underrepresented regions, expand community-based epidemiological studies, and integrate cross-border surveillance strategies to mitigate disease importation risks. By addressing these gaps, KSA can enhance its preparedness and contribute to global NTD elimination efforts.
| S-EPMC11893951 | biostudies-literature
Project description:OBJECTIVE:Investigate if there is an association between apical periodontitis and diabetes mellitus. MATERIAL AND METHODS:A bibliographic search was performed on Medline/PubMed, Scopus and Cochrane databases using the keywords apical periodontitis and diabetes mellitus. Published papers written in English and performed on animals or humans were included. Meta-analysis was performed using the OpenMeta (analyst) tool for the statistical analysis. The variables analyzed were the prevalence of Apical Periodontitis (AP) among teeth and patients with Diabetes Mellitus (DM). RESULTS:Of the total studies found, only 21 met the inclusion criteria. Ten clinical studies on animals, ten studies on humans and a systematic review were included. Meta-analysis shows that the prevalence of teeth with apical periodontitis among patients with diabetes mellitus has an odds ratio of 1.166 corresponding to 507 teeth with AP + DM and 534 teeth with AP without DM. The prevalence of patients with AP and DM shows an odds ratio of 1.552 where 91 patients had AP + DM and 582 patients AP without DM. CONCLUSION:Scientific evidence suggests that there could be a common physiopathological factor between apical periodontitis and diabetes mellitus but more prospective studies are needed to investigate the association between these two diseases.
| S-EPMC7074097 | biostudies-literature
Project description:ObjectivesLow back pain (LBP) has a major impact on health workers, and its prevalence and risk factors among them in Saudi Arabia have been investigated previously. However, the results have never been comprehensively reviewed. Therefore, the aim of this study was to perform a systematic review and meta-analysis of the available literature to identify the prevalence and risk factors of LBP among health workers in Saudi Arabia.MethodsMEDLINE/PubMed, Web of Science, Scopus, CINAHL, and Saudi peer-reviewed journals were searched for relevant literature. After quality assessment of the eligible articles, 18 studies targeting seven occupational categories, with a total number of 5345 health workers, were analyzed.ResultsPooled prevalence rates of 40.8% (n = 7 studies), 65.0% (n = 13 studies), and 81.4% (n = 2 studies) were obtained for week, year, and career, respectively, across all professional groups. Nurses and physical therapists were more susceptible to LBP, in that order, than the other categories considering week and career periods. Age, body mass index, and female gender were the most commonly reported individual risk factors. Occupational risk factors mainly included work-related activities requiring back bending and twisting, lifting and pulling objects, and manual patient-handling.ConclusionsThe results of this review indicate that LBP is highly prevalent among health workers in Saudi Arabia when compared with international rates. Proper prophylactic measures are necessary to reduce LBP and minimize its consequences. Further high-quality research is needed in different Saudi regions to achieve a broader understanding of LBP prevalence and causes.
| S-EPMC7382437 | biostudies-literature
Project description:BackgroundStress urinary incontinence (SUI) is a prevalent condition among women in Saudi Arabia, characterized by involuntary urine leakage during physical activities that increase abdominal pressure, such as coughing or sneezing. This systematic review and meta-analysis aimed to evaluate the prevalence of SUI and identify its key risk factors.MethodsA comprehensive search of PubMed, Scopus, and Web of Science was conducted for studies published up to July 2024, following PRISMA 2020 guidelines.ResultsTen observational studies involving 18,245 participants met the inclusion criteria, and study quality was assessed using the Newcastle-Ottawa Scale. A random-effects model was employed for meta-analysis, with subgroup and sensitivity analyses performed to address heterogeneity. The pooled prevalence of SUI was 26% (95% CI: 14-41%, I2 = 99%, p < 0.001), with rates ranging from 3.3% to 50%. Subgroup analysis showed a prevalence of 17% (95% CI: 1-42%, I2 = 99%, p < 0.001) in the general population and 33% (95% CI: 19-48%, I2 = 99%, p < 0.001) in specific groups, such as postpartum women and those with low back pain. Significant risk factors included age, obesity, high parity, and chronic conditions like diabetes. Despite high heterogeneity, sensitivity analyses confirmed the robustness of these findings.ConclusionsThe findings underscore the need for public health strategies focused on weight management, pelvic floor rehabilitation, and increased awareness about SUI. Effective preventive measures could significantly reduce the burden of SUI and improve the quality of life for women in Saudi Arabia.
| S-EPMC11640814 | biostudies-literature