NEGR1 Modulates Mouse Affective Discrimination by Regulating Adult Olfactory Neurogenesis.

ABSTRACT:

Background

Affective recognition and sensory processing are impaired in people with autism. However, no mouse model of autism comanifesting these symptoms is available, thereby limiting the exploration of the relationship between affective recognition and sensory processing in autism and the molecular mechanisms involved.

Methods

With Negr1 ^-/- mice, we conducted the affective state discrimination test and an odor habituation/dishabituation test. Data were analyzed using the k-means clustering method. We also employed a whole-cell patch clamp and bromodeoxyuridine incorporation assay to investigate underlying mechanisms.

Results

When encountering mice exposed to restraint stress or chronic pain, wild-type mice discriminated between them by eit

SUBMITTER: Kim KH 

PROVIDER: S-EPMC11338060 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature