Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice.

ABSTRACT:

Background

Intestinal epithelial cells (IECs) serve as robust barriers against potentially hostile luminal antigens and commensal microbiota. Epithelial barrier dysfunction enhances intestinal permeability, leading to leaky gut syndrome (LGS) associated with autoimmune and chronic inflammatory disorders. However, a causal relationship between LGS and systemic disorders remains unclear. Ap1m2 encodes clathrin adaptor protein complex 1 subunit mu 2, which facilitates polarized protein trafficking toward the basolateral membrane and contributes to the establishment of epithelial barrier functions.

Methods

We generated IEC-specific Ap1m2-deficient (Ap1m2^ΔIEC) mice with low intestinal barrier integrity as an LSG model and examined the systemic impact.

Findings

A

SUBMITTER: Kinashi Y 

PROVIDER: S-EPMC11338063 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature