KIT in oocytes: a key factor for oocyte survival and reproductive lifespan.

ABSTRACT:

Background

The KITL-KIT interaction is known as an important initiator in oocyte activation through the downstream pathway of PI3K-AKT-FOXO3 signalling. Previous studies utilising germ cell-specific Kit mutant knockin and kinase domain knockout models with Vasa-Cre suggested the crucial role of KIT in oocyte activation at the primordial follicle stage.

Methods

We utilised mice with complete postnatal deletion of KIT expression in oocytes via Gdf9-iCre and conducted analyses on ovarian follicle development, specific markers, hormone assays, and fertility outcomes.

Findings

Our findings reveal contrasting phenotypes compared to previous mouse models with prenatal deletion of Kit. Specifically, postnatal deletion of Kit exhibit no defects in germ cell nest breakdown, fol

SUBMITTER: Luan Y 

PROVIDER: S-EPMC11338130 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature