Brain Chimeroids reveal individual susceptibility to neurotoxic triggers.

ABSTRACT: Interindividual genetic variation affects the susceptibility to and progression of many diseases^1,2. However, efforts to study how individual human brains differ in normal development and disease phenotypes are limited by the paucity of faithful cellular human models, and the difficulty of scaling current systems to represent multiple people. Here we present human brain Chimeroids, a highly reproducible, multidonor human brain cortical organoid model generated by the co-development of cells from a panel of individual donors in a single organoid. By reaggregating cells from multiple single-donor organoids at the neural stem cell or neural progenitor cell stage, we generate Chimeroids in which each donor produces all cell lineages of the cerebral cortex, even when using pluripoten

SUBMITTER: Anton-Bolanos N 

PROVIDER: S-EPMC11338177 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature