Molluscum contagiosum virus protein MC089 inhibits interferon regulatory factor 3 activation.

ABSTRACT: Molluscum contagiosum virus (MCV) is a human-specific poxvirus that causes a highly common but mild infection characterized by distinctive and persistent papular skin lesions. These lesions can persist for long periods without an effective clearance response from the host. MCV, like all poxviruses, encodes multiple known immunosuppressive proteins which target innate immune signalling pathways involved in viral nucleic acid sensing, interferon production and inflammation which should trigger antiviral immunity leading to clearance. Two major families of transcription factors responsible for driving the immune response to viruses are the NF-κB and the interferon regulatory factor (IRF) families. While NF-κB broadly drives pro-inflammatory gene expression and IRFs chiefly drive interferon in

SUBMITTER: Al Hamrashdi M 

PROVIDER: S-EPMC11338640 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature