The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation.

ABSTRACT: Evolutionary adaptation of multicellular organisms to a closed gut created an internal microbiome differing from that of the environment. Although the composition of the gut microbiome is impacted by diet and disease state, we hypothesized that vertebrates promote colonization by commensal bacteria through shaping of the apical surface of the intestinal epithelium. Here, we determine that the evolutionarily ancient FOXA transcription factors control the composition of the gut microbiome by establishing favorable glycosylation on the colonic epithelial surface. FOXA proteins bind to regulatory elements of a network of glycosylation enzymes, which become deregulated when Foxa1 and Foxa2 are deleted from the intestinal epithelium. As a direct consequence, microbial composition shifts dramatic

SUBMITTER: Swisa A 

PROVIDER: S-EPMC11338728 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature