Prefrontal-Limbic Circuitry Is Associated With Reward Sensitivity in Nonhuman Primates.

ABSTRACT:

Background

Abnormal reward sensitivity is a risk factor for psychiatric disorders, including eating disorders such as overeating and binge-eating disorder, but the brain structural mechanisms that underlie it are not completely understood. Here, we sought to investigate the relationship between multimodal whole-brain structural features and reward sensitivity in nonhuman primates.

Methods

Reward sensitivity was evaluated through behavioral economic analysis in which monkeys (adult rhesus macaques; 7 female, 5 male) responded for sweetened condensed milk (10%, 30%, 56%), Gatorade, or water using an operant procedure in which the response requirement increased incrementally across sessions (i.e., fixed ratio 1, 3, 10). Animals were divided into high (n = 6) or low (n = 6) rewa

SUBMITTER: Hur KH 

PROVIDER: S-EPMC11338745 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature