Platelet indices and the risk of pulmonary arterial hypertension: a two-sample and multivariable Mendelian randomization study.

ABSTRACT:

Background

Recent epidemiological studies have indicated a correlation between platelet indices and pulmonary arterial hypertension (PAH), yet the causality between them remains unclear. To explore the causal relationship between four platelet indices and PAH, with the aim of providing a theoretical basis for clinical prevention and treatment.

Methods

Single-nucleotide polymorphisms (SNPs) associated with platelet-related traits were selected as exposure factors from published genome-wide association studies (GWAS), including: platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW). Summary-level data for PAH were obtained from the FinnGen study (248 cases and 289,117 controls). Two-sample and multivariable Mendelian random

SUBMITTER: Li Y 

PROVIDER: S-EPMC11338760 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature