Syndecan-1 as a predictor of vulnerable atherosclerotic plaques.

ABSTRACT:

Aims

Cardiovascular disease remains a major global health concern, with atherosclerosis (AS) being a significant contributor. Vulnerable plaques play a critical role in acute cardiovascular events. Syndecan-1 (SDC-1), a vital membrane proteoglycan in the vascular endothelial glycocalyx, is believed to be associated with plaque progression. However, its precise relationship with severity and vulnerability of atherosclerotic plaque remains unclear. This study aimed to investigate SDC-1 expression and its potential correlation with plaque vulnerability in ApoE^-/- atherosclerosis mouse model.

Methods and results

Eight-week-old mice were induced into the AS model using a high-fat diet (HFD) and/or partial ligation of the left common carotid artery (PLCA), with a chow d

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC11338802 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature