The association between circulating irisin levels and osteoporosis in women: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Objective

This systematic review and meta-analysis aimed to investigate the association between circulating irisin levels and osteoporosis in women, exploring irisin's potential role in the pathophysiology and management of osteoporosis.

Method

We searched PubMed, Embase, Web of Science, Cochrane Library, CNKI, WanFang, and VIP databases up to January 2023. The inclusion criteria were observational studies reporting on circulating irisin levels in women. The standardized mean difference (SMD) and correlation coefficients with a 95% confidence interval (CI) were used as the main effect measures under a random-effects model. Heterogeneity was evaluated using the Cochrane Q statistic and the I² statistics. Subgroup analysis and univariate meta-regression analy

SUBMITTER: Shen X 

PROVIDER: S-EPMC11338845 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature