Unveiling potential drug targets for lung squamous cell carcinoma through the integration of druggable genome and genome-wide association data.

ABSTRACT: Background: Lung squamous cell carcinoma (LSCC) is a major subtype of lung cancer with poor prognosis and low survival rate. Compared with lung adenocarcinoma, yet no FDA-approved targeted-therapy has been found for lung squamous cell carcinoma. Methods: To identify potential drug targets for LSCC, Summary-data-based Mendelian randomization (SMR) analysis was used to examine the potential association between 4,543 druggable genes and LSCC, followed by colocalization analysis and HEIDI tests to confirm the robustness of the result. Phenome-wide association study (PheWAS) explored potential side effects of candidate drug targets. Enrichment analysis and protein-protein interaction networks revealed the function and significance of therapeutic targets. Single-cell expression ana

SUBMITTER: Wu W 

PROVIDER: S-EPMC11338847 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature