Citrulline and ADI-PEG20 reduce inflammation in a juvenile porcine model of acute endotoxemia.

ABSTRACT:

Background

Arginine is a conditionally essential amino acid that is depleted in critically ill or surgical patients. In pediatric and adult patients, sepsis results in an arginine-deficient state, and the depletion of plasma arginine is associated with greater mortality. However, direct supplementation of arginine can result in the excessive production of nitric oxide (NO), which can contribute to the hypotension and macrovascular hypo-reactivity observed in septic shock. Pegylated arginine deiminase (ADI-PEG20, pegargiminase) reduces plasma arginine and generates citrulline that can be transported intracellularly to generate local arginine and NO, without resulting in hypotension, while maintaining microvascular patency. The objective of this study was to assess the efficacy of AD

SUBMITTER: Vonderohe C 

PROVIDER: S-EPMC11338849 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature