Causality between various cytokines and asthma: a bidirectional two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Many studies have shown that cytokines play an important role in the pathogenesis of asthma, but their biological effects on asthma remain unclear. The Mendelian randomization (MR) method was used to evaluate the causal relationship between various cytokines [such as interleukins (ILs), interferons (IFNs), tumor necrosis factors (TNFs), colony-stimulating factors (CSFs), transforming growth factor (TGF), etc.,] and asthma.

Methods

In this study, inverse variance weighting was used to evaluate the causal relationship between asthma and cytokines. In addition, the reliability of the results is ensured by multiple methods such as MR-Egger, weighted median, MR-Raps, MR-Presso, and RadialMR, as well as sensitivity analysis.

Results

The results showed that none o

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC11338859 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature