Acute kidney injury development is associated with mortality in Japanese patients with cirrhosis: impact of amino acid imbalance.

ABSTRACT:

Background

Acute kidney injury (AKI) is a serious complication of cirrhosis. This study analyzed the prognostic effect of AKI in patients with cirrhosis and its risk factors, particularly in relation to amino acid imbalance.

Methods

This retrospective study reviewed 808 inpatients with cirrhosis at two institutes in Gifu, Japan. AKI was diagnosed according to the recommendations of the International Club of Ascites. Amino acid imbalance was assessed by measuring serum branched-chain amino acid (BCAA) levels, tyrosine levels, and the BCAA-to-tyrosine ratio (BTR). Factors associated with mortality and AKI development were assessed using the Cox proportional hazards regression model with AKI as a time-dependent covariate and the Fine-Gray competing risk regression model, respec

SUBMITTER: Miwa T 

PROVIDER: S-EPMC11338968 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature