Integrative bioinformatics analysis to identify ferroptosis-related genes in non-obstructive azoospermia.

ABSTRACT:

Purpose

The objective of this study was to discern ferroptosis-related genes (FRGs) linked to non-obstructive azoospermia and investigate the associated molecular mechanisms.

Method

A dataset related to azoospermia was retrieved from the Gene Expression Omnibus database, and FRGs were sourced from GeneCards. Ferroptosis-related differentially expressed genes (FRDEGs) were discerned. Subsequently, these genes underwent analyses encompassing Gene Ontology and Kyoto Encyclopedia of Genes and Genomes, as well as protein-protein interaction (PPI) networks and assessments of functional similarity. Following the identification of hub genes, an exploration of immune infiltration, single-cell expression, diagnostic utility, and interactions involving hub genes, RNA-binding proteins (

SUBMITTER: Hong Y 

PROVIDER: S-EPMC11339017 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature