Determinants of cognitive dysfunction in adults with sickle cell-related stroke or suspected neurological morbidity.

ABSTRACT:

Abstract

The prognosis of sickle cell disease (SCD) in adults is determined primarily by damage to targeted organs such as the brain. Cognitive dysfunction in SCD is a common chronic neurological manifestation, but studies remain mostly descriptive in adults. The objective of this study was to better characterize the cognitive profile and the association between cognitive dysfunction and brain lesions. We included adult patients with SCD referred for a neurological assessment. An adapted battery of neuropsychological tests was used to assess cognitive deficits. Brain or arterial abnormalities were assessed using brain magnetic resonance imaging/magnetic resonance angiography and a cervical and transcranial Doppler ultrasound. The cognitive profile of 96 patients was characterized b

SUBMITTER: Messimeris D 

PROVIDER: S-EPMC11339041 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature