Effectiveness of metformin pretreatment for stroke severity: A propensity score matching study.

ABSTRACT:

Background and objective

Metformin pretreatment might have neuroprotective effects. We aimed to determine the therapeutic effects of the antidiabetic medication metformin on ischemic stroke severity and discharge outcomes.

Methods

We analyzed data on 1303 ischemic stroke patients who were on antidiabetic medications from the Massachusetts General Hospital (MGH) Advanced Comprehensive Stroke Center dataset (n = 8943, 2012-2022). We applied propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) analyses to investigate the effect of current usage of metformin (versus alternate antidiabetic treatment) on acute stroke clinical severity and discharge outcomes.

Results

Of the 1303 patients who were on antidiabetic medications at the time of str

SUBMITTER: Zhang B 

PROVIDER: S-EPMC11339120 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature