Peritoneal infection after colorectal cancer surgery induces substantial alterations in postoperative protein levels: an exploratory study.

ABSTRACT:

Purpose

Peritoneal infection, due to anastomotic leakage, after resection for colorectal cancer have been shown to associate with increased cancer recurrence and mortality, as well as cardiovascsular morbidity. Alterations in circulating protein levels could help shed light on the underlying mechanisms, prompting this exploratory study of 64 patients operated for colorectal cancer with anastomosis.

Methods

Thirty-two cases who suffered a postoperative peritoneal infection were matched with 32 controls who had a complication-free postoperative stay. Proteins in serum samples at their first postoperative visit and at one year after surgery were analysed using proximity extension assays and enzyme-linked immunosorbent assays. Multivariate projection methods, adjusted for multip

SUBMITTER: Grahn O 

PROVIDER: S-EPMC11339184 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature