Spironolactone use and oocyte maturation in patients undergoing controlled ovarian hyperstimulation.

ABSTRACT:

Purpose

To evaluate the association between spironolactone use and controlled ovarian hyperstimulation (COH) outcomes.

Methods

Retrospective study, including patients who underwent COH. Oocyte yield and maturation rates were compared by categories of spironolactone use at the start of their cycle.

Results

402 patients were included. 83 patients continued spironolactone, 44 patients discontinued spironolactone, and 275 matched control patients were spironolactone-naïve. No difference was observed in the number of oocytes retrieved (17 ± 14 vs. 15 ± 13, p = 0.4) or mature oocytes vitrified (15 ± 9.5 vs. 12 ± 11, p = 0.4) in patients who continued spironolactone use and spironolactone naïve patients, respectively. When comparing patients who continued spironolactone use

SUBMITTER: Ghofranian A 

PROVIDER: S-EPMC11339222 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature