Cryopreserved nanostructured fibrin-agarose hydrogels are efficient and safe hemostatic agents.

ABSTRACT: Uncontrolled bleeding during surgery is associated with high mortality and prolonged hospital stay, necessitating the use of hemostatic agents. Fibrin sealant patches offer an efficient solution to achieve hemostasis and improve patient outcomes in liver resection surgery. We have previously demonstrated the efficacy of a nanostructured fibrin-agarose hydrogel (NFAH). However, for the widespread distribution and commercialization of the product, it is necessary to develop an optimal preservation method that allows for prolonged stability and facilitates storage and distribution. We investigated cryopreservation as a potential method for preserving NFAH using trehalose. Structural changes in cryopreserved NFAH (Cryo-NFAH) were investigated and comparative in vitro and in vivo efficacy and s

SUBMITTER: Casado C 

PROVIDER: S-EPMC11339259 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature